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junior college 1 | H3 Maths
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Date Posted: 7 years ago
Views: 440
https://en.wikipedia.org/wiki/Williamson_ether_synthesis
https://www.masterorganicchemistry.com/2014/01/10/synthesis-3-reactions-of-alkyl-halides/
Use CH3CH2Cl and (CH3)2CHOH
The Williamson Synthesis typically done in the presence of strong base.
The halide (chloroethane is primary), favouring SN2 reaction and E2 elimination is less favoured.
If you use CH3CH2OH and (CH3)2CHCl, the halide is a secondary halide, Thus, the competing E2 elimination (forming the more substituted alkene as per Zaitsev's rule ) could prevent high yields.
Read the links for more info.
https://www.masterorganicchemistry.com/2014/01/10/synthesis-3-reactions-of-alkyl-halides/
Use CH3CH2Cl and (CH3)2CHOH
The Williamson Synthesis typically done in the presence of strong base.
The halide (chloroethane is primary), favouring SN2 reaction and E2 elimination is less favoured.
If you use CH3CH2OH and (CH3)2CHCl, the halide is a secondary halide, Thus, the competing E2 elimination (forming the more substituted alkene as per Zaitsev's rule ) could prevent high yields.
Read the links for more info.
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Date Posted:
7 years ago
Can help with thermodynamics . Pls pls pls
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